The number 16 is the fourth number in the numbers sequence. Below is a list of the appearances of this number in chronological order by episode, and the number 16 in real life.

In Lost:

Season 1:

"Pilot: Part 1"-

• Jack says the first spinal surgery operation he did was on a 16 year old girl.
• Jack, Charlie and Kate find the pilot 16 hours after the plane crash.

"Pilot: Part 2"-

• Danielle Rousseau's transmission was running for 16 years.

"White Rabbit"-

• Jack told the ticket agent at the airport that he

"Confidence Man"-

• Sawyer needs $160,000 to con Jessica.
• The date on the calender in the bar is June 16th.

"Numbers"-

• Hurley was the first person to win the lottery in 16 weeks.

"Exodus: Part 2"-

• Hurley paid a man $1600 for the scooter.

Season 2:

"Man of Science, Man of Faith"-

• Desmond was peddling at 16 miles per hour on the exercise bike.

"Everybody Hates Hugo"-

• One of the pumps at the gas station had 16 on it.

"Abandoned"-

• Shannon said she would be working at her internship for 16 hours.

"Maternity Leave"-

• Alex is 16 years old.

"Lockdown"-

• Anthony Cooper's safety deposit box was 1516.

"Two for the Road"-

• One of the police cars had 16 on it.

"?"-

• A system failure occurred September 22, 2004 at 16:16 (4:16 PM), which was later discovered to be the reason of the plane crash.

Season 3:

"The Glass Ballerina"-

• Jae Lee's hotel room number was 1516.

"Left Behind"-

• Juliet enters the code 1623 in the sonic fence keypad.

"Through the Looking Glass"-

• The keypad in the Looking Glass has 16 keys.

Season 4:

"The Economist"-

• The time on Daniel's second clock is 3:16:23

In Real Life:

• The current Pope is Pope Benedict XVI.
• Each player has 16 pieces to start with in the game of chess.
• The average person is awake for 16 hours of a day.