Locke was in a wheelchair for four years. He was defenestrated by his father, Anthony Cooper at his 8th floor apartment. His disability caused many people to say he cannot do something. Locke would always say "Don't tell me what I can't do". After the plane crash. Locke miraculous was able to walk. Locke also was in the wheelchair in his vision with Boone. Locke has become afraid that if he gets off the Island, he will be confined to the wheelchair again

Ben also was in a wheelchair after his surgery on his spine. Michael was in a wheelchair when he was run over by a car. Also, Rose saw many crutches and a wheelchair at the faith healer's house.